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Research ArticleAdult Brain
Open Access

Machine Learning–Based Prediction of Small Intracranial Aneurysm Rupture Status Using CTA-Derived Hemodynamics: A Multicenter Study

Z. Shi, G.Z. Chen, L. Mao, X.L. Li, C.S. Zhou, S. Xia, Y.X. Zhang, B. Zhang, B. Hu, G.M. Lu and L.J. Zhang
American Journal of Neuroradiology April 2021, 42 (4) 648-654; DOI: https://doi.org/10.3174/ajnr.A7034
Z. Shi
aFrom the Department of Diagnostic Radiology (Z.S., C.S.Z., B.H., G.M.L., L.J.Z.), Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China
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G.Z. Chen
bDepartment of Medical Imaging (G.Z.C.), Nanjing First Hospital, Nanjing, Jiangsu, China
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L. Mao
cDeepwise AI Lab (L.M., X.L.L.), Beijing, China
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X.L. Li
cDeepwise AI Lab (L.M., X.L.L.), Beijing, China
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C.S. Zhou
aFrom the Department of Diagnostic Radiology (Z.S., C.S.Z., B.H., G.M.L., L.J.Z.), Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China
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S. Xia
dDepartment of Radiology (S.X.), Tianjin First Central Hospital, Tianjin, China
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Y.X. Zhang
eLaboratory of Image Science and Technology (Y.X.Z.), School of Computer Science and Engineering, Southeast University, Nanjing, China
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B. Zhang
fDepartment of Radiology (B.Z.), Taizhou People’s Hospital, Taizhou, Jiangsu, China
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B. Hu
aFrom the Department of Diagnostic Radiology (Z.S., C.S.Z., B.H., G.M.L., L.J.Z.), Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China
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G.M. Lu
aFrom the Department of Diagnostic Radiology (Z.S., C.S.Z., B.H., G.M.L., L.J.Z.), Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China
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L.J. Zhang
aFrom the Department of Diagnostic Radiology (Z.S., C.S.Z., B.H., G.M.L., L.J.Z.), Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China
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  • FIG 1.
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    FIG 1.

    Flow chart of this study. RA indicates ruptured aneurysm; URA, Unruptured aneurysms; CFD, computational fluid dynamics.

  • FIG 2.
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    FIG 2.

    Performance of the SVM algorithm, the derived top 10 variables, and the performances of feature—dependent models in the internal validation dataset. A, ROC curves and AUCs for training and internal and external validation sets. B, The top 10 features of the variables derived from the SVM algorithm. C, ROCs of the SVM based on the features belonging to the 3 categories separately in the internal validation dataset.

Tables

  • Figures
  • Performance of SVM to predict rupture status of small aneurysms in the training, internal validation, and external validation datasets

    Training Set (n = 410)Internal Validation Set (n = 94)External Validation Set (n = 52)Tianjin Set (n = 30)Taizhou Set (n = 22)
    AUC0.880.910.820.710.90
    95% CI0.85–0.920.74–0.980.69–0.940.52–0.860.70–0.99
    Sensitivity73.4%77.3%68.2%54.5%81.8%
    Specificity91.1%84.2%76.7%73.7%81.8%
    Delong test––.21a–.15b
    • Note:—CI indicates confidence interval; LR, logistic regression; SVM, support vector machine; RF, random forest; ROC, receiver operation characteristic; RF, random forest; -, NA.

    • ↵a P < . 05 means a significant difference exists in AUCs of SVM in the internal and external validation datasets.

    • ↵b P < . 05 means a significant difference exists in AUCs of SVM in Taizhou and Tianjin sets.

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American Journal of Neuroradiology: 42 (4)
American Journal of Neuroradiology
Vol. 42, Issue 4
1 Apr 2021
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Cite this article
Z. Shi, G.Z. Chen, L. Mao, X.L. Li, C.S. Zhou, S. Xia, Y.X. Zhang, B. Zhang, B. Hu, G.M. Lu, L.J. Zhang
Machine Learning–Based Prediction of Small Intracranial Aneurysm Rupture Status Using CTA-Derived Hemodynamics: A Multicenter Study
American Journal of Neuroradiology Apr 2021, 42 (4) 648-654; DOI: 10.3174/ajnr.A7034

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Machine Learning–Based Prediction of Small Intracranial Aneurysm Rupture Status Using CTA-Derived Hemodynamics: A Multicenter Study
Z. Shi, G.Z. Chen, L. Mao, X.L. Li, C.S. Zhou, S. Xia, Y.X. Zhang, B. Zhang, B. Hu, G.M. Lu, L.J. Zhang
American Journal of Neuroradiology Apr 2021, 42 (4) 648-654; DOI: 10.3174/ajnr.A7034
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