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Research ArticleADULT BRAIN
Open Access

Retention of Gadolinium-Based Contrast Agents in Multiple Sclerosis: Retrospective Analysis of an 18-Year Longitudinal Study

Y. Forslin, S. Shams, F. Hashim, P. Aspelin, G. Bergendal, J. Martola, S. Fredrikson, M. Kristoffersen-Wiberg and T. Granberg
American Journal of Neuroradiology July 2017, 38 (7) 1311-1316; DOI: https://doi.org/10.3174/ajnr.A5211
Y. Forslin
aFrom the Departments of Clinical Science Intervention and Technology (Y.F., S.S., F.H., P.A., G.B., J.M., M.K.-W., T.G.)
bRadiology (Y.F., S.S., F.H., P.A., G.B., J.M., M.K.-W., T.G.)
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  • ORCID record for Y. Forslin
S. Shams
aFrom the Departments of Clinical Science Intervention and Technology (Y.F., S.S., F.H., P.A., G.B., J.M., M.K.-W., T.G.)
bRadiology (Y.F., S.S., F.H., P.A., G.B., J.M., M.K.-W., T.G.)
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F. Hashim
aFrom the Departments of Clinical Science Intervention and Technology (Y.F., S.S., F.H., P.A., G.B., J.M., M.K.-W., T.G.)
bRadiology (Y.F., S.S., F.H., P.A., G.B., J.M., M.K.-W., T.G.)
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P. Aspelin
aFrom the Departments of Clinical Science Intervention and Technology (Y.F., S.S., F.H., P.A., G.B., J.M., M.K.-W., T.G.)
bRadiology (Y.F., S.S., F.H., P.A., G.B., J.M., M.K.-W., T.G.)
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G. Bergendal
aFrom the Departments of Clinical Science Intervention and Technology (Y.F., S.S., F.H., P.A., G.B., J.M., M.K.-W., T.G.)
bRadiology (Y.F., S.S., F.H., P.A., G.B., J.M., M.K.-W., T.G.)
cNeurology (G.B., S.F.)
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J. Martola
aFrom the Departments of Clinical Science Intervention and Technology (Y.F., S.S., F.H., P.A., G.B., J.M., M.K.-W., T.G.)
bRadiology (Y.F., S.S., F.H., P.A., G.B., J.M., M.K.-W., T.G.)
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S. Fredrikson
cNeurology (G.B., S.F.)
dClinical Neuroscience (S.F.), Karolinska Institutet, Stockholm, Sweden.
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M. Kristoffersen-Wiberg
aFrom the Departments of Clinical Science Intervention and Technology (Y.F., S.S., F.H., P.A., G.B., J.M., M.K.-W., T.G.)
bRadiology (Y.F., S.S., F.H., P.A., G.B., J.M., M.K.-W., T.G.)
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T. Granberg
aFrom the Departments of Clinical Science Intervention and Technology (Y.F., S.S., F.H., P.A., G.B., J.M., M.K.-W., T.G.)
bRadiology (Y.F., S.S., F.H., P.A., G.B., J.M., M.K.-W., T.G.)
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American Journal of Neuroradiology: 38 (7)
American Journal of Neuroradiology
Vol. 38, Issue 7
1 Jul 2017
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Cite this article
Y. Forslin, S. Shams, F. Hashim, P. Aspelin, G. Bergendal, J. Martola, S. Fredrikson, M. Kristoffersen-Wiberg, T. Granberg
Retention of Gadolinium-Based Contrast Agents in Multiple Sclerosis: Retrospective Analysis of an 18-Year Longitudinal Study
American Journal of Neuroradiology Jul 2017, 38 (7) 1311-1316; DOI: 10.3174/ajnr.A5211

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Retention of Gadolinium-Based Contrast Agents in Multiple Sclerosis: Retrospective Analysis of an 18-Year Longitudinal Study
Y. Forslin, S. Shams, F. Hashim, P. Aspelin, G. Bergendal, J. Martola, S. Fredrikson, M. Kristoffersen-Wiberg, T. Granberg
American Journal of Neuroradiology Jul 2017, 38 (7) 1311-1316; DOI: 10.3174/ajnr.A5211
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Cited By...

  • MR Imaging Signs of Gadolinium Retention Are Not Associated with Long-Term Motor and Cognitive Outcomes in Multiple Sclerosis
  • Does Gadolinium Deposition Lead to Metabolite Alteration in the Dentate Nucleus? An MRS Study in Patients with MS
  • Safety of Gadolinium-Based Contrast Agents in Patients with Stage 4 and 5 Chronic Kidney Disease: a Radiologists Perspective
  • Cumulative gadodiamide administration leads to brain gadolinium deposition in early MS
  • Signal Hyperintensity on Unenhanced T1-Weighted Brain and Cervical Spinal Cord MR Images after Multiple Doses of Linear Gadolinium-Based Contrast Agent
  • Gadolinium Retention in the Brain: An MRI Relaxometry Study of Linear and Macrocyclic Gadolinium-Based Contrast Agents in Multiple Sclerosis
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This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Gadolinium Retention: A Research Roadmap from the 2018 NIH/ACR/RSNA Workshop on Gadolinium Chelates
    Robert J. McDonald, Deborah Levine, Jeffrey Weinreb, Emanuel Kanal, Matthew S. Davenport, James H. Ellis, Paula M. Jacobs, Robert E. Lenkinski, Kenneth R. Maravilla, Martin R. Prince, Howard A. Rowley, Michael F. Tweedle, Herbert Y. Kressel
    Radiology 2018 289 2
  • Gadolinium-based Contrast Media, Cerebrospinal Fluid and the Glymphatic System: Possible Mechanisms for the Deposition of Gadolinium in the Brain
    Toshiaki Taoka, Shinji Naganawa
    Magnetic Resonance in Medical Sciences 2018 17 2
  • Gadolinium retention after administration of contrast agents based on linear chelators and the recommendations of the European Medicines Agency
    Ilona A. Dekkers, Rick Roos, Aart J. van der Molen
    European Radiology 2018 28 4
  • Gadolinium-Based MRI Contrast Agents Induce Mitochondrial Toxicity and Cell Death in Human Neurons, and Toxicity Increases With Reduced Kinetic Stability of the Agent
    Danielle V. Bower, Johannes K. Richter, Hendrik von Tengg-Kobligk, Johannes T. Heverhagen, Val M. Runge
    Investigative Radiology 2019 54 8
  • Gadolinium: pharmacokinetics and toxicity in humans and laboratory animals following contrast agent administration
    Julie Davies, Petra Siebenhandl-Wolff, Francois Tranquart, Paul Jones, Paul Evans
    Archives of Toxicology 2022 96 2
  • Gadolinium-based contrast agents — review of recent literature on magnetic resonance imaging signal intensity changes and tissue deposits, with emphasis on pediatric patients
    Einat Blumfield, David W. Swenson, Ramesh S. Iyer, A. Luana Stanescu
    Pediatric Radiology 2019 49 4
  • Gadolinium-based contrast agents in children
    Michael N. Rozenfeld, Daniel J. Podberesky
    Pediatric Radiology 2018 48 9
  • A Review of the Current Evidence on Gadolinium Deposition in the Brain
    Richard Pullicino, Mark Radon, Shubhabrata Biswas, Maneesh Bhojak, Kumar Das
    Clinical Neuroradiology 2018 28 2
  • Exposure to gadolinium and neurotoxicity: current status of preclinical and clinical studies
    Carlo A. Mallio, Àlex Rovira, Paul M. Parizel, Carlo C. Quattrocchi
    Neuroradiology 2020 62 8
  • Current and Future MR Contrast Agents
    Eric Lancelot, Jean-Sébastien Raynaud, Pierre Desché
    Investigative Radiology 2020 55 9

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